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Christoph Ladel Selected Research

fibroblast growth factor 18

1/2021The effects of sprifermin on symptoms and structure in a subgroup at risk of progression in the FORWARD knee osteoarthritis trial.
1/2021Long-term structural and symptomatic effects of intra-articular sprifermin in patients with knee osteoarthritis: 5-year results from the FORWARD study.
11/2018A Novel High Sensitivity Type II Collagen Blood-Based Biomarker, PRO-C2, for Assessment of Cartilage Formation.
12/2017Sprifermin (rhFGF18) modulates extracellular matrix turnover in cartilage explants ex vivo.

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Christoph Ladel Research Topics

Disease

9Osteoarthritis
01/2022 - 01/2015
4Knee Osteoarthritis
05/2021 - 01/2021
3Pain (Aches)
12/2021 - 01/2021
3Inflammation (Inflammations)
01/2021 - 11/2011
2Sepsis (Septicemia)
10/2008 - 03/2005
1Rheumatoid Arthritis
01/2021
1Necrosis
12/2017
1Osteophyte
01/2017
1Synovitis
01/2015
1Fibrosis (Cirrhosis)
01/2014
1Nephritis
01/2014
1Proteinuria
01/2014
1Lupus Nephritis
01/2014
1Experimental Arthritis
11/2011
1Arthritis (Polyarthritis)
11/2011
1Bacterial Infections (Bacterial Infection)
10/2005
1Body Weight (Weight, Body)
03/2005

Drug/Important Bio-Agent (IBA)

5Pharmaceutical PreparationsIBA
01/2022 - 01/2014
5Biomarkers (Surrogate Marker)IBA
01/2022 - 01/2015
4fibroblast growth factor 18IBA
01/2021 - 12/2017
2Collagen Type II (Type II Collagen)IBA
08/2020 - 11/2011
1C-Reactive ProteinIBA
01/2021
1catch-relaxing peptide (Mytilus)IBA
01/2021
1Matrix Metalloproteinases (MMPs)IBA
08/2020
1Aggrecans (Aggrecan)IBA
08/2020
1Intercellular Signaling Peptides and Proteins (Growth Factors)IBA
11/2018
1Insulin-Like PeptidesIBA
11/2018
1Oncostatin MIBA
12/2017
1Mycophenolic Acid (Cellcept)FDA LinkGeneric
01/2014
1Immunosuppressive Agents (Immunosuppressants)IBA
01/2014
1Antigen-Antibody Complex (Immune Complex)IBA
01/2014
1AutoantibodiesIBA
01/2014
1periodate-oxidized adenosine 5'-triphosphateIBA
11/2011
1Purinergic Receptors (Receptors, Purine)IBA
11/2011
12',3'-dialdehyde ATPIBA
11/2011
1Biological ProductsIBA
10/2008
1Anti-Bacterial Agents (Antibiotics)IBA
10/2005
1acyldepsipeptidesIBA
10/2005
1UracilIBA
03/2005
1azasteneIBA
03/2005

Therapy/Procedure

3Therapeutics
12/2021 - 01/2014
1Knee Replacement Arthroplasty (Total Knee Replacement)
10/2015